Chronic myeloid leukemia (CML) accounts for 15%–20% of all adult leukemias. Leukemia has among the highest mortalities of any cancer. Here, we provide an overview of the clinical presentation and cellular biology of different phenotypes of Ph-positive leukemia and highlight key findings regarding leukemogenesis. Besides CML, the Ph is found in acute lymphoblastic leukemia, acute myeloid leukemia, and mixed-phenotype acute leukemia. Each BCR-ABL1 transcript is present in a distinct leukemia phenotype, which predicts both response to therapy and clinical outcome. During the progression of CML from the chronic phase to the accelerated phase and then to the blast phase, the expression patterns of different BCR-ABL1 transcripts vary. The kinase activity is responsible for maintaining proliferation, inhibiting differentiation, and conferring resistance to cell death. This aberrant fusion gene encodes the breakpoint cluster region-proto-oncogene tyrosine-protein kinase (BCR-ABL1) oncogenic protein with persistently enhanced tyrosine kinase activity. In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stability. Would also love to respond to the Axe-Fx's responses to what I send it, but again, I can only do that if I make a controller from scratch - not possible from the BCR.The truncated chromosome 22 that results from the reciprocal translocation t(9 22)(q34 q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). I could only do that if I made a MIDI controller from scratch - I believe it's impossible to do with the BCR. i'd like to be able to use two knobs to scroll through the grid, and another knob to select an effect, but that's just not the way it works. I'm able to place effects on the grid now. Haven't reconfigured to monitor the Editor yet, but I don't think I'll need to anymore, except for any instructions that may have been completely undocumented. looked up the old sysex spec doc, and gleaned many helpful details from that, and also realized I was only monitoring the Axe-Fx's responses, not what the Editor's actually sending out. Should be easier going from here, but still slow. syx send to the BCR like firmware updates for the Axe are or if it's something different. Not sure how easy it will be to share the config after I'm done. just enough to have left the daylight behind me, but not enough to see his furniture or the exit. So far, I've only been experimenting with Amp1, so I'm not too far into the rabbit hole. I'm not getting anything from MIDI-Ox when that happens. I have no idea how the Editor places effects on the grid.
#Bc manager bcr 2000 drivers
And yes, you have to dig into the SysEx.Īnd the BC Manager program is extremely helpful (make sure to read/skim at least around the first 40 pages of its manual to know which BCR modes, firmwares, and drivers will actually work - I'm using mode S4 since it was easiest to configure and I only need to mess with a setting on my MIDI interface between using the BCR and using the Editor, but I was toggling between mode U1 and S4, restarting BC Manager each time to use the USB connection at first). Third, fourth, fifth, and sixth knobs are controlling Bass, Mids, Treble, and Presence, respectively, and they also have a push-to-set-default config attached. Unfortunately/fortunately, the push-to-default doesn't talk to the rotary function, so rotating it goes back to where it left off. Second knob is controlling the Amp1 Drive, defaults to the Amp1 default value (5.98), and pushing it immediately sets the default value. Push it again, and it goes back to the first bank. Push it again, increments the bank again. I have the first one set to scroll through presets 0-127. So, in a BCR preset, I have the first six rotary push encoders set for Axe-Fx functions. It's slow going, running the Editor, MIDI-Ox, and a program called BC Manager synchronously with the Axe, BCR, and my MIDI interface, but I'm making progress. Right now I just have a few of the rotary push encoders (knobs) configured.
0 kommentar(er)
